Tag: chiral

More Science, Less Fiction, Man-Made Molecules

More Science, Less Fiction, Man-Made Molecules

Science and molecules go “hand in hand”.

Science is my passion. And by hand in hand I’m talking about the right and left.  My first full length novel, Paradox: The Alien Genome, was first an ember from Dr. Neil deGrasse Tyson, a morsel from one of his The Incredible Universe science episodes. He discussed in some detail the nature of chiral molecules, their ‘handedness’, and how on Earth amino acids natural link up and tweak one direction, while the molecules that link up as sugars link in the opposite direction. He said he’d like to read a book about astronauts on a planet where the spirals were reversed.

science - caraway or spearmint?
Same molecule, different flavors?

So I wrote it.  (By the way, Dr. Tyson, I’d love to send you an autographed copy!) And it was a journey of discovery as I researched DNA and chiral bonds. Thalidomide is a chiral molecule. Unbeknownst to its creators, if they could force the molecule in the other direction, it would not have caused birth defects in fetuses back in the late 50s. I found long and detailed information about this and I nearly took a vacation from my novel to investigate the science further.

Synthesized Proteins

Most molecules are chiral. We can make these things in the laboratory and change them, creating totally new things but with the same atomic structure. A couple months back, I received a link to an article about two MIT chemists, Zachary P. Gates and Brad Pentelute, who could synthesize millions of novel, non-natural proteins to be used as drugs against Ebola and other viruses. They call it Xenoprotein etching. Critically, these man-made structures don’t have to be kept refrigerated. This enhances not only their shelf life, but also their potential use. They can be delivered “in the field” where disease lurks. People wouldn’t have to travel to clinics or doctors. In developing populations, transportation is not always available. When time is of the essence, days could mean lives.

MIT Chemists Synthesize Proteins. 

Why Science Matters

I had to reflect on their ingenuity and how their work ‘mirrors’ (sorry, I couldn’t resist) to some degree my imaginary DNA splicing Malaria vaccine that replicated itself into the haploid cells of the children of vaccinated humans. Through some complex biochemical, yet founded in reality, sci-fi technobabble, this leads to sterility. Humans were unable to create a molecule that was reversed (and which divided, not like sugar which is static). They embarked on a hunting trip in space that lasted two years. They hoped to finding living creatures with this reversed chirality in their DNA. If you’ve read the novel, you know the rest. If not, I won’t give spoilers.

Nevertheless, this article proves once again that no matter how far-fetched of a thing a science fiction writer can dream up, it might very well be possible. We may not be able to transverse space faster than light, but perhaps in the future. I’m sure the Greeks and Romans 3000 years ago never thought of flying commercially, or to another planet. Technology hadn’t come far enough. It’s barely been 100 years since we abandoned the horse and buggy for fossil fueled vehicles. And don’t forget the saying of the Boomer Generation: If we can go to the moon, we can (fill in the blank with any impossible task, like, cure cancer, go solar, stop war).

That’s what makes writing science fiction so much fun. I like to think we are more enlightened and educated enough to leap beyond our current civilization, to question all that we are, and what we could be. I refer to the forward thinking sci-fi, not the, apocalyptic, dystopian, doom and gloom, an earth ruined by war sci fi. And a wise person once said – “Be careful what you ask for. You might get it.” I certainly hope so!

Based on Reality

If you’re a Star Trek fan,enjoy the tales of Michael Crichton (Jurrasic Park, ER, Congo), the works of Isaac Asimov, you may discover just what you’re looking for here.  Do you like hard sci fi, medical missions, runaway bacteria, asteroids, and aliens?  You will enjoy my two series, The Pioneer Missions, and the as yet untitled full length novels about an intrepid star ship captain who finds his soul mate in an alien . Find all my work here.

 

Homochirality – the foundation of life

Homochirality – the foundation of life

This is interesting as hell if you are a geek. If you’re too busy ranting about the election, sitting in front of a game console, or watching soaps, go ahead and skip this post. For those of you still with me, we’re talking about the subject of my first novel, PARADOX. We’re talking about chemicals, DNA, atoms, and the forces that make the world go round.

limone

The image above is the molecule LIMONENE. A molecule is a compound of atoms, remember, which are the smallest units of a single element. A center has the neutrons and protons, and in shells around the nucleus zing the electrons. Molecules, like atoms, are three dimensional things. Think of them as Tinkertoys, it helps.

Water is a molecule, made of two hydrogen atoms and one oxygen atom. It is always the same no matter how it combines because the two hydrogen atoms always sit in the outermost shell of the oxygen atom. That will never change.

Most molecules are chiral. They can exist only if the atoms hook up together in the correct order at the correct electron. DNA is one of those molecules. You’ve all seen an illustration showing the twisting molecule, sometimes two meters long, all scrunched up into a microscopic package – it’s truly amazing. All biological DNA but for a few archaic bacteria twist to the right.

Huh? Thglow-dnae only way I can explain it is this: The strips of DNA in the foreground are spiraling down FROM the right in the picture. If you see a drawing of the strips in the foreground going left, it is drawn incorrectly. But that’s not what the post is about. What I want to explain is how it got like this and why it’s important. The geeky part is coming, hang in there.

IT MATTERS which way the thing goes, because if you take a look at the LIMONE molecule above, if it chirals to the left, (L or S) it smells and tastes like lemons. If it spirals to the right (R or D) it smells and tastes like oranges. The molecule cannot match up with it’s own mirror image in 3D. Your hands are like that. The palms can meet, but that is not because they are symmetric. If they were symmetric they would look the same from your viewpoint. Place one over the other in front of you (not palm to palm).They are not mirror images of each other.

Where am I going with this? Remember, salts, minerals, chemicals can and mostly are asymmetrical. All over the world with few exceptions (which I’ll theorize about shortly) amino acids spiral to the right and sugars spiral to the left. In a lab environment, we’ve created compounds that still spiral, but in both directions. Why in nature are these compounds homochiral, but heterochiral in the lab?

soupWhat mechanism drives the biological compounds to homochirality back in the prebiotic world? If you think back to our atoms and their electrons, could it be that a tiny (really tiny) bit of energy happened to pull the molecule a little one way or the other? It could have just as easily been to the left as to the right. This small imbalance in the two different enantiomers is real and in my humble opinion could have been the result of the direction of planetary motion. Earth revolves counterclockwise around the sun and its own axis. By considering the earlier Earth and its molten core, a bit of centrifugal motion may have been the magic ingredient to push biology one direction or another.

I’m at the really geeky part now. If this might be true, then it might be true that on Venus, which spins clockwise on its axis, lifeforms would have the opposite chirality. And here is something we don’t know. How long ago did Venus flip? Most likely, it was early on when the solar system was forming, and models suggest that it was hit by some planetessimal, possibly the fragment of which became Mercury. Another time for that avenue.

So, if Venus were not such a hot and hostile place, would we be able to eat vegetation that arose there or only if it formed before the planet was kicked over? Are the theoretical life forms on Venus opposite from Earthlings and does their DNA spiral left? Are there both biological creatures – those that developed before the collision and after? Wouldn’t it be a fantastic mission, to land on Venus, pick up some creatures, and find out which way they tick?darwin-soup-252x300

More fodder for my science fiction novels, Paradox is exactly this scenario. The planet around Beta Hydri suffered a collision with a space body and was turned upside down so that the sun rises in the west and sets in the east. And the first life forms to develop were similar to Earth – right enantiomer DNA until the planet changed, and then new life forms developed with left enantiomer DNA.

In the last 20 years or so, the classification of biological life forms has itself evolved, and now we have Daredevil Kooky Prince Charles On Friday Goes Surfing. Daredevil stands for DOMAIN, and further divides the kingdoms into Archaea, Bacteria, and Eukarya (this last one holds fungi, plants, and animal kingdoms).  Should we find such life forms, on Mars or one of Jupiter’s moons how will we classify them? Do they get their own Domain or Kingdom,  will they exhibit the D enantiomer or the L, and why? Finding life on another world is more than exciting, it’s an entirely new science to explore. A hundred years ago there was no job for the pizza delivery man. A hundred years from now, I guarantee we will have exobiologists answering these very questions.

 

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