Tag: genetics

Using CRISPR on Human Embryos.

Using CRISPR on Human Embryos.

Augment Khan Noonian Singh

Using CRISPR as we feared could be here. I don’t want to alarm you, but it is here. The Eugenics Wars of Star Trek fame are just another example of Trek fiction about to come true. I’d love to know what your thoughts are on the subject.

Evolution by natural selection is about to end for Homo sapiens.   CRISPR BABIES

I have interrupted my writing jag to bring you this article as soon as I heard about it. Of course, this kind of science is the foundation of my current series, The Jackson Saga. That aside, as this technology is honed and focused, which I think is marvelous, I also worry. I worry that someone “in charge” will be deciding what is a disease, what is a mutation, what’s worth fiddling with, and do we want to end up like the society in GATTACA?

OVERPOPULATION.

I expand on this theme with the biggest single threat

Embryos of augmented humans

to humanity: Overpopulation. I’m not talking numbers of bodies here. I’m talking about the carrying capacity of the planet to support humans and their need for power (yes, both political and electrical). The United States, by the standards of carrying capacity, is the most overpopulated country on the planet. Americans are about 5% of world population and use 20% of the world resources. Americans waste more food, hence energy and political power, than some people have to eat in the whole day.  We use more for cars (tires, gasoline, junkyards), trash (landfills), and especially electricity (air conditioners, big screen televisions, refrigeration).

This could roll on a tangent, but when India and China live their lives at the same standard as Americans (and why shouldn’t they?) overpopulation will finally move to the forefront as the foundation for climate change, food shortages, medical and elderly care issues, with a host of others, including poverty and war (power is both energy and politics).

Genetic Engineering

to remove harmful “whatever” is not my argument. In fact, as I said, Paradox is all about the risk of a genetically engineered vaccine. After administration it carries on in the offspring of vaccinated adults, but with unexpected results. Millions and millions of humans die prematurely or become sterile. When we play with Natural Selection, we must also play with Reproductive Rights. Are those with money, who can afford this medical technology, going to dictate who can and cannot have children without diseases? Will it be available to everyone regardless of their political views or the color of their skin or the money in their bank account?

From the article, I quote:

Gene-editing scientist, Fyodor Urnov* reviewed the Chinese documents said called the undertaking cause for “regret and concern over the fact that gene editing—a powerful and useful technique—was put to use in a setting where it was unnecessary.” Indeed, studies are already under way to edit the same gene in the bodies of adults with HIV. “It is a hard-to-explain foray into human germ-line genetic engineering that may overshadow in the mind of the public a decade of progress in gene editing of adults and children to treat existing disease,” he says.

Stop and Think

I find it a revolutionary tool, and worth exploring to the fullest possible good it can do. I wouldn’t want to wish disabilities on people just to keep the population from explosion, but clear, rules must be in place. We must prevent a group from using this to take power, placing genetic superiority in the hands of the wealthy alone, the political party of party alone, or, without looking forward to reduce the chances of a “Eugenics War”.  If one race becomes so powerful the world over, humans will lose the diversity of our evolution. We are amazing animals, adapted to various climates, producing different cultures, and having the ability to see that we have so much more in common than we we have as differences. Let us keep what makes us human, and remove what hurts us most.

This is indeed a slippery slope, but an adventurous one to be sure. Talk about the Final Frontier. We should let Nature run the most of the show. It’s done a pretty fair job so far.

 

*associate director of the Altius Institute for Biomedical Sciences, a nonprofit in Seattle, Washington.

Books

 

More Science, Less Fiction, Man-Made Molecules

More Science, Less Fiction, Man-Made Molecules

Science and molecules go “hand in hand”.

Science is my passion. And by hand in hand I’m talking about the right and left.  My first full length novel, Paradox: The Alien Genome, was first an ember from Dr. Neil deGrasse Tyson, a morsel from one of his The Incredible Universe science episodes. He discussed in some detail the nature of chiral molecules, their ‘handedness’, and how on Earth amino acids natural link up and tweak one direction, while the molecules that link up as sugars link in the opposite direction. He said he’d like to read a book about astronauts on a planet where the spirals were reversed.

science - caraway or spearmint?
Same molecule, different flavors?

So I wrote it.  (By the way, Dr. Tyson, I’d love to send you an autographed copy!) And it was a journey of discovery as I researched DNA and chiral bonds. Thalidomide is a chiral molecule. Unbeknownst to its creators, if they could force the molecule in the other direction, it would not have caused birth defects in fetuses back in the late 50s. I found long and detailed information about this and I nearly took a vacation from my novel to investigate the science further.

Synthesized Proteins

Most molecules are chiral. We can make these things in the laboratory and change them, creating totally new things but with the same atomic structure. A couple months back, I received a link to an article about two MIT chemists, Zachary P. Gates and Brad Pentelute, who could synthesize millions of novel, non-natural proteins to be used as drugs against Ebola and other viruses. They call it Xenoprotein etching. Critically, these man-made structures don’t have to be kept refrigerated. This enhances not only their shelf life, but also their potential use. They can be delivered “in the field” where disease lurks. People wouldn’t have to travel to clinics or doctors. In developing populations, transportation is not always available. When time is of the essence, days could mean lives.

MIT Chemists Synthesize Proteins. 

Why Science Matters

I had to reflect on their ingenuity and how their work ‘mirrors’ (sorry, I couldn’t resist) to some degree my imaginary DNA splicing Malaria vaccine that replicated itself into the haploid cells of the children of vaccinated humans. Through some complex biochemical, yet founded in reality, sci-fi technobabble, this leads to sterility. Humans were unable to create a molecule that was reversed (and which divided, not like sugar which is static). They embarked on a hunting trip in space that lasted two years. They hoped to finding living creatures with this reversed chirality in their DNA. If you’ve read the novel, you know the rest. If not, I won’t give spoilers.

Nevertheless, this article proves once again that no matter how far-fetched of a thing a science fiction writer can dream up, it might very well be possible. We may not be able to transverse space faster than light, but perhaps in the future. I’m sure the Greeks and Romans 3000 years ago never thought of flying commercially, or to another planet. Technology hadn’t come far enough. It’s barely been 100 years since we abandoned the horse and buggy for fossil fueled vehicles. And don’t forget the saying of the Boomer Generation: If we can go to the moon, we can (fill in the blank with any impossible task, like, cure cancer, go solar, stop war).

That’s what makes writing science fiction so much fun. I like to think we are more enlightened and educated enough to leap beyond our current civilization, to question all that we are, and what we could be. I refer to the forward thinking sci-fi, not the, apocalyptic, dystopian, doom and gloom, an earth ruined by war sci fi. And a wise person once said – “Be careful what you ask for. You might get it.” I certainly hope so!

Based on Reality

If you’re a Star Trek fan,enjoy the tales of Michael Crichton (Jurrasic Park, ER, Congo), the works of Isaac Asimov, you may discover just what you’re looking for here.  Do you like hard sci fi, medical missions, runaway bacteria, asteroids, and aliens?  You will enjoy my two series, The Pioneer Missions, and the as yet untitled full length novels about an intrepid star ship captain who finds his soul mate in an alien . Find all my work here.

 

A recent review

A recent review

Shameless plug: another 5 star review of Paradox. If you haven’t read it yet, what are you waiting for? Click the picture and get the e-version instantly! Read it? Rate it! Read more stories with many of the same characters: Jackson, Quixote, Rianya, Bala, Lee, Watson, Bailey, Dukvita, the Kiians, and a new species coming up – the Zlogers!

 

If you long for the days of Gene Roddenberry’s soulful Star Trek, or hope the Avatar movie might one day become a reality, then you are in for a treat with H.S. Rivney’s Paradox: The Alien Genome. The suggestion of a genetic cure from the world beyond captivated my imagination, as did the author’s writing style. For me, the vivid, unique descriptions illuminated this space odyssey to movie-screen proportions. A healthy dose of dialogue keeps the pace at warp speed with lots of techie jargon. But what really impressed me was the author’s sophisticated scientific knowledge—I would believe her to be an astronaut or a physicist in a previous life to dream up the concepts presented throughout the novel. The author creates a totally convincing world from ecosystems to geology, animal species to alien beings. One graphic scene was tasteful, accurate and evocative. But there’s a touch of intrigue and danger, as well as a softer side to this story, too. A great ending wraps up this exciting futuristic journey after traveling back to a nostalgic era of Kirk, Spock, and Sulu— I highly recommend the ride!

Patti Cavaliere, author of 5 star rated “Looking for Leo”, click me!

Goodreads Giveaway

Goodreads Giveaway

gilesemooncoverStarts today! runs through the end of January – enter for a chance to win a signed copy of Paradox: The Alien Genome. Share with those who love Hard Science Fiction, this will take you from the vastness of our galaxy to the microcosm of molecules!  Castaway astronauts may never see Earth again, which is a shame since what humanity needs most is all around them.

Enter to Win!

#amwriting #sciencefiction #startrek

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